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However, it should not be ruled out that SARS-CoV-2 mRNA vaccines could also generate autoimmune responses in genetically susceptible individuals upon exposure to viral antigens, as observed in some cases (76β81), but as the mRNA degrades and does not persist in the organism (88), the long-term autoimmune sequelae could be limited and disappear once the triggering antigen is removed, as occurs in many cases of ASIA syndrome (74) 5 Similarity in genetic predisposition Single nucleotide polymorphisms (SNPs) in several genes associated with autoimmune diseases have been observed in patients with ME/CFS ( In addition, there is evidence that patients with ME/CFS have associations between elevated fatigue and specific SNPs in TNF-Ξ±, IL1b, IL4, and IL6 genes (90)
